Between the past and the future, sanity and madness, dreams and reality, lies the mystery of the Twelve Monkeys... The year is 2035 and human kind subsists in a desolate netherworld following the eradication of 99% of the earth's population, a holocaust that makes the planet's surface uninhabitable and mankind's destiny uncertain. Cole (Bruce Willis) a reluctant volunteer aided by Dr. Kathryn Railly (Madeline Stowe) have only two clues to solve the puzzle of the Twelve Monkeys which threatens to completely erase humanity from the planet...